At Livingspring Family Medical Center, we understand that managing chronic kidney disease (CKD) can be complex and confusing. It’s often driven by genetic factors that go undetected through standard testing. That’s why we offer the Renasight™ genetic test, an advanced, comprehensive solution designed to uncover the underlying genetic causes of CKD—giving you and your healthcare team the insights needed for better management, earlier intervention, and peace of mind.
Chronic kidney disease (CKD) affects millions of Americans and is often caused by conditions such as:
Diabetes – the leading cause of kidney failure, due to high blood sugar damaging kidney filtration over time.
High blood pressure (hypertension) – which can stress and scar delicate kidney blood vessels.
Heart disease – which can impair blood flow and kidney function.
Lifestyle factors – including obesity, smoking, or poor diet.
In addition to these common causes, genetics play a major role. Many kidney diseases are inherited or influenced by genetic variants that may run in families. Without testing, these causes may remain unknown and untreated.
Early detection is critical. Many people do not realize they have kidney disease until it has already progressed. Testing allows for:
Early intervention – treating high blood pressure, blood sugar, or genetic risks before kidneys are permanently damaged
Slower progression – protecting kidney function with medications and lifestyle changes
Better health outcomes – reducing risk of dialysis or transplant in the future
Family health awareness – helping relatives know if they are at risk for inherited kidney disorders
Renasight™ is a next-generation sequencing panel that analyzes 397 genes known to be associated with chronic kidney disease. This comprehensive kidney gene panel can help determine whether your kidney condition has a hereditary cause or runs in your family.
It utilizes a simple blood or saliva sample, collected either in-clinic or at home, and delivers detailed results in approximately three weeks.
Genetic testing with Renasight™ offers several key benefits:
Unlocks the Cause – It helps identify the root cause of CKD and predict how it may progress.
Guides Personalized Care – Benefits decision-making around treatments, medication interventions, and specialist referrals.
Supports Family Risk Awareness – Helps assess whether family members may also be at increased risk.
Potential Clinical Trial Eligibility – Findings could qualify you for advanced, targeted interventions.
Moreover, organizations such as the National Kidney Foundation (NKF) and KDIGO now recommend genetic testing as part of CKD evaluation due to its diagnostic and therapeutic value. Research shows that Renasight™ has practical clinical utility—identifying actionable findings that informed patient management in nearly 89% of cases.
In a study of over 1,000 patients, Renasight™ identified a monogenic kidney disorder in about 21%, with an additional 3.9% carrying high-risk genetic variants (like APOL1). Nearly half of the individuals were carriers of recessive variants with implications for their children—even if they were asymptomatic.
Among Black participants, 34.5% had a positive genetic finding, and 75% of those involved APOL1 high-risk variants—underscoring the importance of testing in at-risk populations.
One case study highlighted how genetic diagnosis of COL4A4-related Alport Syndrome transformed treatment—avoiding unnecessary immunosuppression and enabling better family planning.
Consultation & Test Order
Your healthcare provider will discuss whether Renasight™ is right for you and place the order.
Sample Collection
Provide a blood draw at our facility or submit a saliva sample from home.
Receive Results
In about three weeks, a comprehensive, clinically actionable report will be made available. You’ll also have access to a genetic counseling session if needed.
Personalized Follow-Up
Your provider will help interpret the results and integrate them into a tailored care plan for you—and your family if relevant.
Cutting-Edge Genetic Diagnostics – Access to one of the most comprehensive kidney gene panels.
Expert Guidance & Support – We facilitate sample collection, provide results review, and coordinate genetic counseling.
Insurance-Friendly & Affordable – Most patients carry minimal or no out-of-pocket cost, with financial assistance available when needed.
Research-Backed – Our service is aligned with leading CKD guidelines and backed by robust clinical evidence.
Understanding the genetic basis of your kidney condition can change how you—and your providers—approach your care. Whether it’s initiating earlier treatment, adjusting medication, uncovering at-risk relatives, or exploring specialized therapies, Renasight™ can be a pivotal tool.
Contact Livingspring Family Medical Center today to learn more about Renasight™ genetic testing for kidney disease, and how we can help you take control of your kidney health.